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Study identifier: NCT07177300 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)

Condition: Sickle Cell Anemia (HbSS) · Sickle-β0-thalassemia (HbSβ0)  ·  Sponsor: Children's Hospital Medical Center, Cincinnati

PhasePhase 4
Planned participants50
Who can joinAll sexes, 6 Months to no upper limit
Healthy volunteersNo

About this study

The main reason for this research study is to learn more about hydroxyurea and the treatment of sickle cell anemia (SCA). Hydroxyurea is a medication that has been studied for many years and has been shown to provide benefits for people with SCA. In this research study, the investigators hope to learn more about how to improve the dosing and monitoring of hydroxyurea and learn more about the long-term effects of hydroxyurea over time. Hydroxyurea is usually dosed based only on your weight. Our study will use a new way to select a starting dose that is based on how each patient absorbs hydroxyurea.

This description comes directly from the study's public registry record.

Talk to the study team

Wendi L. Long, Sr. Regulatory Specialist, BS, CCRC  ·  513-803-3064  ·  wendi.long@cchmc.org

Teresa Latham, Research Director, DrPH  ·  (513) 803-7922  ·  teresa.latham@cchmc.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cincinnati Children's Hospital Medical CenterCincinnati, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07177300