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Study identifier: NCT07176689 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

Condition: Desmoid Tumor · Aggressive Fibromatosis  ·  Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

PhasePhase 4
Planned participants50
Who can joinFemale, 18 Years to 40 Years
Healthy volunteersNo

About this study

This study is being conducted to study how nirogacestat may affect the ovarian function of adult premenopausal women with progressing desmoid tumors/aggressive fibromatosis.

This description comes directly from the study's public registry record.

Talk to the study team

US Medical Information  ·  888-275-7376  ·  eMediUSA@emdserono.com

Always discuss trial participation with your own doctor first.

Locations (23)

Cliniques Universitaires Saint-Luc (CUSL)Brussels, BelgiumRecruiting
Universitaetsmedizin MannheimMannheim, GermanyRecruiting
IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l.Meldola, Forli-Cesena, ItalyRecruiting
La Fondazione e l'Istituto di CandioloCandiolo, Torino, ItalyRecruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant OrsolaBologna, ItalyRecruiting
IRCCS Istituto Ortopedico Rizzoli di BolognaBologna, ItalyRecruiting
Fondazione IRCCS Istituto Nazionale dei Tumori MilanoMilan, ItalyRecruiting
Istituto Nazionale Tumori I.R.C.C.S- Fondazione G. PascaleNaples, ItalyRecruiting
Policlinico Universitario Campus Bio-MedicoRoma, ItalyRecruiting
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)Amsterdam, NetherlandsRecruiting
Academisch Ziekenhuis LeidenLeiden, NetherlandsRecruiting
Hospital de la Santa Creu i Sant PauBarcelona, SpainRecruiting

+ 11 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07176689