Condition: Advanced Unresectable Hepatocellular Carcinoma · Sponsor: Riboscience, LLC.
RBS2418 is a targeted immune modulator that inhibits ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). It is designed to promote anti-tumor immunity by preserving endogenous 2'-3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from hydrolysis, thereby activating antigen-presenting cells and promoting robust T cell activation. Ideally, RBS2418 acts synergistically with CTLA-4 inhibitors, such as those in the STRIDE regimen (Tremelimumab plus Durvalumab). The hypothesis is that RBS2418 combined with STRIDE will be safe, well-tolerated, highly immunogenic, and enhance anti-tumor responses in adult participants with advanced, unresectable hepatocellular carcinoma (HCC) compared to STRIDE alone.
This description comes directly from the study's public registry record.
Riboscience Clinical Trials · 415-754-3182 · clinicaltrials@riboscience.com
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| Johns Hopkins | Baltimore, Maryland, United States | Recruiting |
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee, United States | Recruiting |
| University of Texas Southwestern | Dallas, Texas, United States | Recruiting |
| START Dallas Fort Worth | Fort Worth, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07175441