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Study identifier: NCT07175051 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

Condition: Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) · Albuminuria  ·  Sponsor: University of Illinois at Chicago

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

Sickle cell anemia (SCA) is an inherited red blood disorder. The kidneys are among the most commonly affected organ systems in SCA. The Food and Drug Administration (FDA) has approved empagliflozin as a treatment to reduce the decline of kidney function in those with kidney disease. The proposed research study aims to determine whether empagliflozin can prevent the progression of kidney dysfunction in patients with sickle cell anemia (SCA) who are at high risk of developing advanced chronic kidney disease (CKD).

This description comes directly from the study's public registry record.

Talk to the study team

Santosh L Saraf, MD  ·  312-996-5680  ·  ssaraf@uic.edu

Anand Srivastave, MD

Always discuss trial participation with your own doctor first.

Locations (1)

University of Illinois Chicago, Sickle Cell CenterChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07175051