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Study identifier: NCT07174336 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Condition: Breast Neoplasms · Neoplasm Metastasis  ·  Sponsor: Eli Lilly and Company

PhasePhase 3
Planned participants920
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of the study is to assess the efficacy and safety of the addition of Tersolisib (LY4064809/STX-478) to other anti-cancer drugs as first treatment for advanced hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Participants can remain in the study as long as the drug is helping the cancer without unbearable side effects.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (338)

Alaska Oncology and HematologyAnchorage, Alaska, United StatesNot Yet Recruiting
Ironwood Cancer & Research CentersChandler, Arizona, United StatesNot Yet Recruiting
Mayo Clinic in Arizona - PhoenixPhoenix, Arizona, United StatesNot Yet Recruiting
The University of Arizona Cancer Center - North CampusTucson, Arizona, United StatesNot Yet Recruiting
Genesis Cancer and Blood InstituteHot Springs, Arkansas, United StatesNot Yet Recruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
Community Cancer InstituteClovis, California, United StatesNot Yet Recruiting
City of HopeDuarte, California, United StatesNot Yet Recruiting
Epic Care - EmeryvilleEmeryville, California, United StatesNot Yet Recruiting
Marin Cancer CareGreenbrae, California, United StatesRecruiting
Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - IrvineIrvine, California, United StatesNot Yet Recruiting
City of Hope Orange County Lennar Foundation Cancer CenterIrvine, California, United StatesNot Yet Recruiting

+ 326 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07174336