Condition: Reumatoid Arthritis · Interstitial Lung Disease Due to Systemic Disease (Disorder) · Idiopathic Pulmonary Fibrosis (IPF) · Sponsor: Azienda Unita Sanitaria Locale di Piacenza
Lung involvement is one of the most frequent extra articular involvements of rheumatoid arthritis (RA). RA related lung involvement can affect parenchyma, airway, vascular tree and serosa. Among all possible manifestations of lung disease, interstitial lung disease is the most severe being able to compromise quality of life and survival and involves about 20% of patients with rheumatoid arthritis (RA). However, chest high resolution computed tomography (HRCT) features of RA, with or without interstitial lung involvement, have not been clearly defined. Such features have been mostly investigated on small populations of RA patients, often including patients with connective tissue diseases (CTDs), namely systemic sclerosis, mixed connective tissue disease, idiopathic inflammatory myopathies, making difficult to discriminate possible specific features of RA interstitial lung disease (ILD). The aims of this observational longitudinal study are to investigate: i) chest HRCT features of RA (frequency of radiologic HRCT patterns, fibrosis, nodules, bronchiectasis, etc.), associated or not to ILD; ii) possible associations between chest HRCT features and demographic, clinical and serologic characteristics of RA; iii) specific chest HRCT features of RA ILD, compared to idiopathic pulmonary fibrosis (IPF) and CTD ILD (i.e., primary Sjogren syndrome, idiopathic inflammatory myopathies, etc), according to the Centres availability. Consecutive, unselected, DICOM files of chest HRCT of ad…
This description comes directly from the study's public registry record.
Marco Sebastiani, MD · +39 0523302645 · m.sebastiani@ausl.pc.it
Francesca Cozzini, M.D. · +39 0523302645 · f.cozzini@ausl.pc.it
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| Institute of Rheumatology, Na Slupi 4 | Prague, Czechia | Not Yet Recruiting |
| UOC Reumatologia, Arcipedale Sant'Anna | Ferrara, Italy | Recruiting |
| SC Malattie Apparato Respiratorio, Azienda Policlinico di Modena | Modena, Italy | Recruiting |
| Local Health Unit ("Azienda Unità Sanitaria Locale", AUSL) of Piacenza | Piacenza, Italy | Recruiting |
| AUSL-IRCCS di Reggio Emilia | Reggio Emilia, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07174102