Condition: Healthy Volunteers · Nitric Oxide · Vascular Function · Sponsor: Queen Mary University of London
Inorganic nitrate, found in leafy green vegetables and beetroot, can help lower blood pressure and support heart health. Early experimental work has suggested that dietary nitrate supplementation, in the form of beetroot juice or potassium nitrate capsules, can reduce blood pressure and improve endothelial function. Consequently, concentrated nitrate supplements like beetroot juice have become popular. However, these supplements can be expensive, high in sugar, and not to everyone's taste. Since more than three-quarters of adults with high blood pressure live in low- and middle-income countries, it is important to find safe, affordable ways to add nitrate to commonly eaten foods. The team at Queen Mary University of London has been developing nitrate-fortified products that may be more appealing to a wider population. With support from the food manufacturer Reading Scientific Services Ltd. (RSSL), they have successfully added nitrate to three oat-based products: cereal bar, porridge, and biscuits. This study aims to explore whether adding nitrate to commonly eaten foods can improve nitric oxide levels in the body and help lower blood pressure in healthy volunteers. Participants will receive the three nitrate-fortified food products in a randomised, crossover design. Nitrate and nitrite concentrations in biological samples, along with blood pressure, will be measured before and at multiple time points after supplementation with the nitrate-fortified products.
This description comes directly from the study's public registry record.
Amrita Ahluwalia, BSc PhD · +44(0)2078828377 · a.ahluwalia@qmul.ac.uk
Chenguang Wei, BSc PhD · +44(0)7529281905 · chenguang.wei@qmul.ac.uk
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| The William Harvey Research Institute, Centre for Cardiovascular Medicines and Devices, Queen Mary University of London | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07172425