Condition: Cirrhosis · Decompensation · Transjugular Intrahepatic Portosystemic Shunt (TIPS) · Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
The traditional view holds that the natural course of cirrhosis is a unidirectional process, characterized by irreversible progression from the compensated stage to the decompensated stage, and is highly likely to develop further decompensation events or even death. However, a growing body of evidence suggests that the natural course of cirrhosis is not always unidirectional - after the removal of the etiology, the structural and functional changes of the liver may be partially reversed. This understanding has given rise to the concept of "liver recompensation," which has been standardized at the Baveno VII Consensus Conference. Notably, in a cohort of patients with alcohol-related cirrhosis, 18% achieved recompensation, which was significantly associated with a reduction of more than 90% in liver-related mortality. In patients with hepatitis B-related cirrhosis, 6% achieved recompensation after treatment with nucleos(t)ide analogs, with a similar improvement in mortality. Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established therapy for complications related to portal hypertension, including gastroesophageal variceal bleeding, refractory ascites, and hepatic hydrothorax. Compared with standard treatment, TIPS has been proven to reduce the incidence of further decompensation and improve transplant-free survival. However, due to portal blood shunting, the risks of abnormal liver function and hepatic encephalopathy (HE) also increase. It is worth noting th…
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Yaowei Bai · +8618627162379 · baiyaowei918@163.com
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| Second Xiangya Hospital, Central South University | Changsha, China | Recruiting |
| The Third Xiangya Hospital of Central South University | Changsha, China | Recruiting |
| Fujian Medical University Union Hospital | Fuzhou, China | Recruiting |
| Huanggang Central Hospital | Huanggang, China | Recruiting |
| Jingzhou Central Hospital | Jingzhou, China | Recruiting |
| Jiangxi Provincial People's Hospital | Nanchang, China | Recruiting |
| The First Affiliated Hospital of Nanjing Medical University | Nanjing, China | Recruiting |
| Shengjing Hospital of China Medical University | Shenyang, China | Recruiting |
| Shanxi Provincial People's Hospital | Taiyuan, China | Recruiting |
| Renmin Hospital of Wuhan University | Wuhan, China | Recruiting |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Wuhan, China | Recruiting |
| Zhongnan Hospital of Wuhan University | Wuhan, China | Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07172035