Condition: Periodontal Diseases · Sponsor: Universidad Complutense de Madrid
Objective: The main aim of this longitudinal clinical study is to evaluate the predictive ability of a panel of salivary biomarkers in determining periodontal health status in 2 years follow up in a group of healthy and periodontally affected individuals. Material and methods: In this longitudinal, observational follow-up study, patients previously enrolled in a cross-sectional study at the Periodontal Postgraduate Clinic, University Complutense of Madrid, will be re-evaluated over a 2-year period. Participants (≥18 years) will be categorized into diagnostic groups based on the 2018 classification of periodontal diseases, including periodontally healthy, gingivitis, treated periodontitis (stable/unstable), and various stages of periodontitis. The study will include follow-up visits at 1 and 2 years. At each visit, participants will undergo a comprehensive medical examination to assess age, gender, weight, height, waist circumference, blood pressure, temperature, smoking and alcohol history, systemic health, and HbA1c levels. A periodontal examination will be performed at six sites per tooth, and clinical parameters including plaque, bleeding on probing, probing depth, recession, and tooth loss will be recorded. Saliva and subgingival plaque samples will be collected for biomarker and microbiological analysis. Salivary biomarkers will be measured using multiplex immunoassays, and bacterial quantification will be performed by multiplex qPCR. Data analyses: Descriptive statisti…
This description comes directly from the study's public registry record.
Elena Figuero, Prof. · +34 913942186 · elfiguer@ucm.es
Mariano Sanz, Prof. · +34 913942021 · marsan@ucm.es
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| Faculty of Dentistry, University Complutense of Madrid (UCM) | Madrid, Spain | Recruiting |
| Faculty of Dentistry, University Complutense of Madrid (UCM) | Madrid, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07167771