Condition: Brain-dead Organ Donors · Sponsor: University Hospital, Grenoble
The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated by preserved spinal activity. Volatile anesthetics may blunt these reflexes, but their potential benefits in this context have never been investigated. This randomized trial evaluates the effects of volatile anesthesia (sevoflurane), opioid administration (sufentanil), or no anesthetic drugs on intraoperative hemodynamic stability during organ procurement in brain-dead donors. The primary outcome is the proportion of operative time within a predefined arterial blood pressure range.
This description comes directly from the study's public registry record.
Benoit CHAMPIGNEULLE, MD, PhD · +33476766879 · BChampigneulle@chu-grenoble.fr
Anaïs ADOLLE · +33476766879 · aadolle@chu-grenoble.fr
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| CHU Grenoble Alpes | Grenoble, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07166991