Condition: Advanced Hepatocellular Carcinoma · Stage III Hepatocellular Carcinoma AJCC v8 · Stage IV Hepatocellular Carcinoma AJCC v8 · Sponsor: NRG Oncology
This phase III trial compares the effect of immunotherapy (IO) with stereotactic body radiation therapy (SBRT) to IO alone in treating patients with liver cancer (hepatocellular cancer) that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). The usual approach is treatment with IO-based drug combinations, such as atezolizumab and bevacizumab, durvalumab and tremelimumab, or ipilimumab and nivolumab. IO with monoclonal antibodies, such as durvalumab, tremelimumab, atezolizumab, nivolumab and ipilimumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor cells. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. SBRT is a type of external radiation therapy that uses special equipment to position a patient and precisely deliver radiation to tumors in the body (except the brain). The total dose of radiation is divided into smaller doses given over several days. This type of radiation therapy helps spare normal tissue. Giving IO with SBRT may be more effective than IO alone in helping patients with advanced hepatocellular cancer live longer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park, California, United States | Recruiting |
| Palo Alto Medical Foundation-Fremont | Fremont, California, United States | Recruiting |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| Palo Alto Medical Foundation-Camino Division | Mountain View, California, United States | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| Palo Alto Medical Foundation Health Care | Palo Alto, California, United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville, California, United States | Recruiting |
| Sutter Roseville Medical Center | Roseville, California, United States | Recruiting |
| Sutter Medical Center Sacramento | Sacramento, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| California Pacific Medical Center-Pacific Campus | San Francisco, California, United States | Recruiting |
+ 127 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07166406