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Study identifier: NCT07164313 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of ZW251 in Participants With Advanced Solid Tumors

Condition: Hepatocellular Carcinoma · Squamous Cell Non-Small Cell Lung Cancer · Germ Cell Tumor  ·  Sponsor: Zymeworks BC Inc.

PhasePhase 1
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out if ZW251, an antibody-drug conjugate targeting glypican-3 (GPC3), is safe and can treat participants with advanced cancers, including hepatocellular carcinoma (HCC), squamous cell non-small cell lung cancer (NSCLC), or germ cell tumors (GCT).

This description comes directly from the study's public registry record.

Talk to the study team

Zymeworks Clinical Trial Resource  ·  (206) 237-1030  ·  medinfo@zymeworks.com

Always discuss trial participation with your own doctor first.

Locations (25)

UCSF Comprehensive Cancer CenterSan Francisco, California, United StatesRecruiting
University of California Los Angeles - Cancer Care - Santa Monica (UCLA)Santa Monica, California, United StatesRecruiting
Norton Cancer InstituteLouisville, Kentucky, United StatesRecruiting
START MidwestGrand Rapids, Michigan, United StatesRecruiting
Hackensack University Medical CenterHackensack, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
START San AntonioSan Antonio, Texas, United StatesRecruiting
START - Dublin Mater Misericordiae University Hospital (MMUH)Dublin, IrelandRecruiting
National Cancer Center EastKashiwa, JapanRecruiting
Kyoto University HospitalKyoto, JapanRecruiting
Kansai Medical University HospitalOsaka, JapanRecruiting

+ 13 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07164313