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Study identifier: NCT07163325 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

EP102 Safety and Efficacy in METTL3 Modulation in Advanced Solid Tumors

Condition: Advanced Solid Tumor (Phase 1)  ·  Sponsor: Epics Therapeutics

PhasePhase 1
Planned participants48
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This the first-in-human (FIH) study for the Investigational Medicinal Product (IMP) EP102, is designed to explore the maximum tolerated dose (MTD), the overall safety profile, its pharmacokinetic (PK) / pharmacodynamic (PD) profile, and an exploratory evaluation of antitumor activity in participants with advanced solid tumors, who have no available standard therapy or who have failed standard therapies. This study will inform on recommended doses for further studies, e.g. dose optimization studies and / or efficacy and safety studies.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Liaison  ·  +32 71 348 500  ·  info@epicstx.com

Always discuss trial participation with your own doctor first.

Locations (11)

Institut Jules BordetBrussels, BelgiumRecruiting
Cliniques universitaires Saint-LucBrussels, BelgiumRecruiting
Universitair Ziekenhuis Gent (UZ Gent) - Drug Research Unit Gent (DRUG)Ghent, BelgiumRecruiting
Leuven Cancer Institute (LKI)Leuven, BelgiumRecruiting
Masaryk Memorial Cancer InstituteBrno, CzechiaRecruiting
Olomouc University HospitalOlomouc, CzechiaRecruiting
Netherlands Cancer Institute (NKI)Amsterdam, NetherlandsRecruiting
University Medical Center Groningen, University of Groningen Department of Medical OncologyGroningen, NetherlandsRecruiting
Hospital Universitari Vall d'Hebron - Vall d'Hebron Institute of OncologyBarcelona, SpainRecruiting
START Madrid - CIOCCMadrid, SpainRecruiting
Hospital Universitario de Santiago de CompostelaSantiago de Compostela, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT07163325