Condition: NK/T-cell Lymphoma · Peripheral T-cell Lymphoma (PTCL) · DLBCL · Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
This study will test whether anti-EBV autologous TCR-T cell injection is safe and effective for patients with relapsed or refractory EBV-positive lymphoma who have HLA-A11:01. Researchers will look at safety, tolerability, and the maximum tolerated dose or recommended dose for future studies. The study will also measure how the infused TCR-T cells expand and persist in the body, changes in EBV DNA levels and T-cell subgroups in the blood, and whether the treatment shows early signs of clinical benefit. Researchers will also explore whether the treatment causes an immune response against the infused cells.
This description comes directly from the study's public registry record.
Xianmin Song, Doctor · +86 18918029692 · shongxm@139.com
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| Shanghai General Hospital | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07162012