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Study identifier: NCT07161037 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

Condition: Autosomal Dominant Polycystic Kidney Disease (ADPKD)  ·  Sponsor: Vertex Pharmaceuticals Incorporated

PhasePhase 2
Planned participants24
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407.

This description comes directly from the study's public registry record.

Talk to the study team

Medical Information  ·  617-341-6777  ·  medicalinfo@vrtx.com

Always discuss trial participation with your own doctor first.

Locations (43)

Alabama Kidney ResearchAlabaster, Alabama, United StatesRecruiting
UAB Nephrology Research at CH19Birmingham, Alabama, United StatesRecruiting
Kaiser Permanente Los Angeles Medical CenterLos Angeles, California, United StatesRecruiting
UCSF Clinical Research Center at ParnassusSan Francisco, California, United StatesRecruiting
Nephrology & Hypertension Associates, PCMiddlebury, Connecticut, United StatesRecruiting
Yale University - Yale Nephrology Clinical Research ClinicNew Haven, Connecticut, United StatesRecruiting
Mayo Clinic - JacksonvilleJacksonville, Florida, United StatesRecruiting
Emory School of Medicine - Renal DivisionAtlanta, Georgia, United StatesRecruiting
Renal AssociatesColumbus, Georgia, United StatesRecruiting
UChicago Medicine - Duchossois Center for Advanced Medicine - NephrologyChicago, Illinois, United StatesRecruiting
University of Iowa Health Care Medical Center- NephrologyIowa City, Iowa, United StatesRecruiting
Clinical & Translational Science Unit (CTSU) - NephrologyKansas City, Kansas, United StatesRecruiting

+ 31 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07161037