Condition: Geographic Atrophy · Age-Related Macular Degeneration · Sponsor: AbbVie
Age-related macular degeneration (AMD) is the abnormal growth of new blood vessels in the light-sensitive tissue at the back of the eye called the retina. Geographic Atrophy (GA) is an advanced form of dry AMD. The purpose of this study is to assess the adverse events and how intravitreal ABBV-6628 moves through the body of adult participants with secondary to age-related macular degeneration ABBV-6628 is an investigational monoclonal antibody fragment being developed for the treatment of geographic atrophy (GA) secondary to (AMD) age-related macular degeneration. Participants in the Stage 1 part will be placed in 1 of 4 groups, called treatment arms. Participants in Stage 2 will be placed into 1 of 2 groups. Each group receives different treatment. Adult participants aged 50 and older years with a diagnosis GA secondary to age-related macular degeneration will be enrolled. Around 66 participants will be enrolled in the study at approximately 27 sites across the US. Participants in Stage 1 will be given ABBV-6628 as an intravitreal injection (injection into the jelly-like tissue that fills the eyeball injection) with dose escalation. Participants in Stage 2 will receive ABBV-6628 or SYFOVRE, an approved treatment for geographic atrophy, administered as per the FDA-approved label. The treatment duration is approximately 22 months and 3 months of follow-up. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants wi…
This description comes directly from the study's public registry record.
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| Retina Partners Midwest, P.C. /ID# 262172 | Carmel, Indiana, United States | Recruiting |
| Sierra Eye Associates /ID# 262142 | Reno, Nevada, United States | Recruiting |
| Retina Research Institute of Texas /ID# 262141 | Abilene, Texas, United States | Recruiting |
| Retina Foundation of the Southwest /ID# 262479 | Dallas, Texas, United States | Recruiting |
| Retina Consultants - The Woodlands /ID# 262138 | The Woodlands, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07160179