Condition: Alzheimer Disease · Preclinical Alzheimer's Disease · Sponsor: Institute for Molecular Medicine
This is a Phase 1, multicenter, randomized, double-blind, placebo-controlled, multiple dose-escalating trial to evaluate the safety, tolerability, and immune response of AV-1980R, an investigational vaccine targeting tau protein, in participants with preclinical Alzheimer's disease. Up to 48 cognitively unimpaired adults aged 65-80 with biomarker evidence of early Alzheimer's disease will be enrolled into three ascending dose cohorts. The study is designed as a secondary prevention trial to test whether therapeutic immunization at the preclinical stage is safe, induces an immune response, and, exploratorily, may favorably affect biomarkers associated with disease progression.
This description comes directly from the study's public registry record.
Roman Kniazev · 7145963981 · rkniazev@immed.org
Anahit Ghochikyan · 7145963981 · aghochikyan@immed.org
Always discuss trial participation with your own doctor first.
| Comprehensive Center for Brain Health | Boca Raton, Florida, United States | Not Yet Recruiting |
| Palm Springs Community Health Center | Miami Lakes, Florida, United States | Recruiting |
| Alzheimer's Research and Treatment Center (Stuart) | Stuart, Florida, United States | Recruiting |
| University of South Florida | Tampa, Florida, United States | Recruiting |
| Alzheimer's Research and Treatment Center (Wellington) | Wellington, Florida, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07158905