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Study identifier: NCT07155226 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

Condition: Acute Lymphoblastic Leukaemia · Acute Myeloid Leukaemia · Higher-risk Myelodysplastic Syndromes  ·  Sponsor: AstraZeneca

PhasePhase 1/Phase 2
Planned participants84
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic malignancies with KMT2Ar, NPM1m, or other genotypes associated with homeobox (HOX) overexpression.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (30)

Research SiteDecatur, Illinois, United StatesRecruiting
Research SiteNew York, New York, United StatesNot Yet Recruiting
Research SiteChapel Hill, North Carolina, United StatesNot Yet Recruiting
Research SiteDurham, North Carolina, United StatesRecruiting
Research SitePortland, Oregon, United StatesSuspended
Research SiteHouston, Texas, United StatesRecruiting
Research SiteFitzroy, AustraliaSuspended
Research SitePerth, AustraliaSuspended
Research SiteToronto, Ontario, CanadaSuspended
Research SiteMontreal, Quebec, CanadaSuspended
Research SiteCopenhagen, DenmarkRecruiting
Research SiteDresden, GermanyRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07155226