Condition: Paroxysmal Nocturnal Hemoglobinuria · Sponsor: Regeneron Pharmaceuticals
This study is researching a treatment combination with two experimental drugs called pozelimab and cemdisiran referred to as "study drugs". Researchers are looking for a better way to treat Paroxysmal Nocturnal Hemoglobinuria (PNH). The aim of the study is to see how well the pozelimab and cemdisiran combination works to lower hemolysis in participants whose PNH has been not well controlled even after taking other complement component 5 (C5) inhibitors, eculizumab/eculizumab biosimilar, ravulizumab or crovalimab. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs? * How much of the study drugs are in the blood at different times? * Whether the body makes antibodies against the study drug (which could make the study drugs not work as well or could lead to side effects)
This description comes directly from the study's public registry record.
Clinical Trials Administrator · 844-734-6643 · clinicaltrials@regeneron.com
Always discuss trial participation with your own doctor first.
| Hospital das Clinicas da FMRP USP | Ribeirão Preto, São Paulo, Brazil | Recruiting |
| Faculdade de Medicina do ABC | Santo André, São Paulo, Brazil | Recruiting |
| CISSS-CA | Lévis, Quebec, Canada | Recruiting |
| Universita Cattolica del Sacro Cuore - Policlinico Universitario A. Gemelli | Rome, Lazio, Italy | Recruiting |
| AOU Careggi | Florence, Tuscany, Italy | Recruiting |
| SC Hematology, AOU Città della Salute e della Scienza di Torino | Torino, Italy | Recruiting |
| In-Vivo Sp. z o.o. | Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland | Recruiting |
| Seoul National University Hospital | Seoul, South Korea | Recruiting |
| Severance Hospital | Seoul, South Korea | Recruiting |
| Seoul St. Mary's Hospital - The Catholic University of Korea | Seoul, South Korea | Recruiting |
| Ewha Womans University Mokdong Hospital | Seoul, South Korea | Recruiting |
| Samsung Medical Center | Seoul, South Korea | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07154745