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Study identifier: NCT07154706 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

Condition: Non-small Cell Lung Cancer (NSCLC)  ·  Sponsor: Nuvation Bio Inc.

PhasePhase 3
Planned participants180
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this phase 3 multicenter double-blind randomized study is to assess the use of taletrectinib in the early-stage non-small cell lung cancer (NSCLC). The study compares taletrectinib (study drug) versus placebo (sugar pill) in patients with ROS1-fusion positive stage IB, II, IIIA NSCLC. The study will evaluate if taletrectinib is better than placebo at preventing the participant's disease from coming back after the participant's lung tumor was removed.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (33)

UCLALos Angeles, California, United StatesRecruiting
UCI Chao Family Comprehensive Cancer CenterOrange, California, United StatesRecruiting
Georgetown University Medical Cener (GUMC)Washington D.C., District of Columbia, United StatesRecruiting
Advent HealthOrlando, Florida, United StatesRecruiting
Saint Alphonsus Health SystemBoise, Idaho, United StatesRecruiting
Tulane Cancer CenterNew Orleans, Louisiana, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Sarah Cannon Research Institute (SCRI) - Texas Oncology-Central SouthAustin, Texas, United StatesRecruiting
MD AndersonHouston, Texas, United StatesRecruiting
Virginia Cancer SpecialistsFairfax, Virginia, United StatesRecruiting

+ 21 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07154706