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Study identifier: NCT07154290 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

Condition: Advanced/Metastatic Non-Small Cell Lung Cancer  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 2
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate two study drugs called ubamatamab and REGN7075, to see if they can help treat advanced or metastatic Non-Small Cell Lung Cancer (NSCLC), and sarilumab, to evaluate to see if it can help with immune-related side effects from ubamatamab. The study is looking at: * How well ubamatamab and REGN7075 works * The side effects that ubamatamab and REGN7075 might cause * How much ubamatamab and REGN7075 is in the blood at different times * If the body makes antibodies to ubamatamab and/or REGN7075, this may cause the ubamatamab to not work as well

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (12)

Cancer Treatment Centers of America, PhoenixGoodyear, Arizona, United StatesRecruiting
The City of Hope Orange County Lennar Foundation Cancer CenterIrvine, California, United StatesRecruiting
Rush University Medical CenterChicago, Illinois, United StatesRecruiting
University of Illinois ChicagoChicago, Illinois, United StatesRecruiting
Franciscan HealthMunster, Indiana, United StatesRecruiting
University of Maryland Greenebaum Comprehensive Cancer CenterBaltimore, Maryland, United StatesRecruiting
Washington University School of MedicineSt Louis, Missouri, United StatesRecruiting
University of Tennessee Medical CenterKnoxville, Tennessee, United StatesRecruiting
Sarah Cannon Research InstituteNashville, Tennessee, United StatesRecruiting
University of Texas Medical BranchGalveston, Texas, United StatesRecruiting
The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Baylor Scott & White HealthTemple, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07154290