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Study identifier: NCT07153029 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Older Adults, Methadone, and Cognitive Function

Condition: Opioid Use Disorder · Cognitive Ability General  ·  Sponsor: University of Maryland, Baltimore

PhaseNA
Planned participants30
Who can joinAll sexes, 55 Years to no upper limit
Healthy volunteersNo

About this study

The increasing prevalence of opioid use disorder (OUD) among older adults, coupled with high overdose rates and cognitive impairments associated with opioid use, highlights a critical gap in addiction treatment. Cognitive impairments can persist despite treatment and negatively impact recovery outcomes, yet cognitive screening and interventions are rarely integrated into OUD care. This study aims to evaluate the feasibility of remotely delivered, smartphone-based cognitive assessments (administered through NeuroUX web-based software) for older adults (55+) in methadone treatment. The tasks have been "gamified" to make them engaging and brief, which could be appealing to patients. They will complete the tasks for 15 days using the phone provided or their own phone. During days 6-15 of testing, tasks will become incrementally more difficult based on participant performance to assess the feasibility of cognitive training. Cognitive training uses engaging games or tasks to strengthen thinking skills like memory and focus, much like physical exercise strengthens the body. Adherence, acceptability, and usability of the tasks will be assessed. Secondary analyses will explore relationships between task performance and participant characteristics (e.g., baseline cognitive functioning, methadone dose, timing of methadone dose). Findings from this pilot study will provide foundational data for a future grant application to develop and test digital cognitive assessment and training inter…

This description comes directly from the study's public registry record.

Talk to the study team

Bethea A Kleykamp, PhD, MA  ·  4104020252  ·  bkleykamp@som.umaryland.edu

Always discuss trial participation with your own doctor first.

Locations (1)

UM Addiction Treatment Programs at 1001 West PrattBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07153029