Condition: IgG4 Related Disease · B-cell Mediated Autoimmune Disorders · Sponsor: Chinese PLA General Hospital
The goal of this clinical trial is to test the safety and potential benefit of a new immune cell therapy called anti-BCMA-CD19 CAR-T cells in adults (18-75 years) with IgG4-related disease (IgG4-RD) that has come back or not improved after standard treatments such as glucocorticoids or rituximab. The main questions this study aims to answer are: * What medical problems (side effects) occur after receiving anti-BCMA-CD19 CAR-T cell therapy? * Does anti-BCMA-CD19 CAR-T cell therapy improve IgG4-RD disease activity scores at 12 weeks and 26 weeks? Participants will: * Have their own blood immune cells collected by a procedure called leukapheresis * Receive short-term chemotherapy to prepare the immune system * Receive one intravenous infusion of anti-BCMA-CD19 CAR-T cells * Return for regular clinic visits over 26 weeks for safety checks, blood tests, and imaging * May be followed for up to one year in total
This description comes directly from the study's public registry record.
YIWEN WANG, M.D. · +86 010-55499314 · yiwenvera@163.com
YUFEI GUO, M.M. · +86 010-55499314 · dt_guoyf0412@outlook.com
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| Department of Rheumatology and Immunology, the First Medical Center, Chinese PLA General Hospital | Beijing, Beijing Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07148791