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Study identifier: NCT07148180 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

Condition: Acute Myeloid Leukaemia (AML) · Leukemia · Blood Cancer  ·  Sponsor: Jacqueline Garcia, MD

PhasePhase 1/Phase 2
Planned participants31
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this research study is to test the safety and efficacy of a new drug combination with three agents, azacitidine, venetoclax and tagraxofusp. Leftover (residual) leukemia disease that is not visible by eye can be increase the chance of disease recurrence. This research study is to determine if the combination therapy can safely help to control residual Acute Myeloid Leukemia (AML) and to prevent disease recurrence. The names of the study drugs involved in this study are: * Tagraxofusp (a type of CD123-directed cytotoxin) * Azacitidine (a type of standard of care cytidine nucleoside analog) * Venetoclax (a type of standard of care BCL-2 inhibitor)

This description comes directly from the study's public registry record.

Talk to the study team

Jacqueline Garcia, MD  ·  617-632-6349  ·  jacqueline_garcia@dfci.harvard.edu

Jacqueline Garcia, MD  ·  jacqueline_garcia@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07148180