Condition: Solid Tumor (Excluding CNS) · Liver Cell Carcinoma · Malignant Rhabdoid Tumor · Sponsor: Seattle Children's Hospital
This Phase 1, open-label, non-randomized study will enroll pediatric and young adult subjects with relapsed or refractory non-central nervous system (CNS) malignant solid tumors expressing glypican-3 (GPC3) to examine the safety, feasibility, and efficacy of administering T cell products derived from peripheral blood mononuclear cells (PBMC) that have been genetically modified to co-express a GPC3-specific chimeric antigen receptor (CAR), interleukin (IL)-15 and IL-21 as well as the inducible caspase 9 (iC9) suicide gene (SC-CAR.GPC3xIL15.21 T cells). A child or young adult meeting all eligibility criteria and meeting none of the exclusion criteria will have a blood sample collected, which will be used to bioengineer the CAR T cells targeting their tumor.
This description comes directly from the study's public registry record.
Michelle Choe, MD · 206-987-2106 · immunotherapy@seattlechildrens.org
Andras Heczey, MD · Andras.Heczey@seattlechildrens.org
Always discuss trial participation with your own doctor first.
| Seattle Children's Hospital | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07148050