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Study identifier: NCT07147348 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as Monotherapy or in Combination With BNT327 in Adults With Advanced Solid Tumors

Condition: Advanced Solid Tumor  ·  Sponsor: BioNTech SE

PhasePhase 1/Phase 2
Planned participants375
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The aim of this first-in-human (FIH) open-label, multi-site study is to evaluate safety, tolerability, pharmacokinetics (PK), immunogenicity and preliminary clinical efficacy of BNT3212, including identification of the recommended dose of BNT3212 for use as monotherapy and with pumitamig (also known as BNT327 or PM8002) as combination therapy, in adults with advanced solid tumors who have exhausted other treatment options.

This description comes directly from the study's public registry record.

Talk to the study team

: BioNTech clinical trials patient information  ·  +49 6131 9084  ·  patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (17)

Cancer Research SAAdelaide, AustraliaRecruiting
Monash Medical CentreClayton, AustraliaRecruiting
Peter MacCallum Cancer CentreMelbourne, AustraliaRecruiting
The Alfred HospitalMelbourne, AustraliaRecruiting
One Clinical ResearchNedlands, AustraliaNot Yet Recruiting
Scientia Clinical Research LimitedRandwick, AustraliaRecruiting
Beijing Cancer HospitalBeijing, ChinaRecruiting
Anhui Provincial HospitalHefei, ChinaRecruiting
First Affiliated Hospital of Xinxiang Medical UniversityHenan, ChinaRecruiting
Hunan Province Cancer HospitalHunan, ChinaNot Yet Recruiting
Shandong University-Jinan Central HospitalShandong, ChinaRecruiting
Qilu Hospital of Shandong University'Shandong, ChinaNot Yet Recruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07147348