Condition: Metastatic Colorectal Adenocarcinoma · Refractory Colorectal Adenocarcinoma · Stage III Colorectal Cancer AJCC v8 · Sponsor: National Cancer Institute (NCI)
This phase I/II trial studies the side effects and best dose of pidnarulex when given together with cemiplimab and to see how well it works in treating patients with microsatellite stable (MSS) colorectal cancer (CRC) that does not respond to treatment (refractory). Pidnarulex may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving pidnarulex with cemiplimab may be safe, tolerable and/or effective in treating patients with refractory MSS CRC.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| MedStar Georgetown University Hospital | Washington D.C., District of Columbia, United States | Recruiting |
| Emory University Hospital Midtown | Atlanta, Georgia, United States | Recruiting |
| Emory University Hospital/Winship Cancer Institute | Atlanta, Georgia, United States | Recruiting |
| Emory Saint Joseph's Hospital | Atlanta, Georgia, United States | Recruiting |
| University of Maryland/Greenebaum Cancer Center | Baltimore, Maryland, United States | Recruiting |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07147231