← Eichor
Study identifier: NCT07147114 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH)

Condition: Combined Pre- and Post-capillary Pulmonary Hypertension · CpcPH · HFmrEF  ·  Sponsor: Gachon University Gil Medical Center

PhasePhase 4
Planned participants64
Who can joinAll sexes, 19 Years to no upper limit
Healthy volunteersNo

About this study

This clinical trial will evaluate whether combination therapy with Dapagliflozin + Macitentan improves outcomes compared to Dapagliflozin + placebo in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH). The study will measure changes in pulmonary vascular resistance, NT-proBNP, 6-minute walk distance, and quality of life (KCCQ scores) over 24 weeks. Participants will be randomly assigned to one of two groups, take study medication for 24 weeks, and undergo regular clinical, laboratory, and safety assessments.

This description comes directly from the study's public registry record.

Talk to the study team

Wook-Jin Chung, MD, PhD  ·  82-32-460-3663  ·  heart@gilhospital.com

Always discuss trial participation with your own doctor first.

Locations (15)

Pusan National University HospitalBusan, South KoreaRecruiting
Chungbuk National University HospitalChungju, South KoreaNot Yet Recruiting
Keimyung University Dongsan HospitalDaegu, South KoreaRecruiting
Chungnam National University HospitalDaejeon, South KoreaRecruiting
Chonnam National University HospitalGwangju, South KoreaRecruiting
Incheon Sejong HospitalIncheon, South KoreaNot Yet Recruiting
Gachon University Gil HospitalIncheon, South KoreaRecruiting
Seoul National University HospitalSeoul, South KoreaRecruiting
Yonsei University Health System, Severance HospitalSeoul, South KoreaNot Yet Recruiting
Asan Medical CenterSeoul, South KoreaRecruiting
Samsung Medical CenterSeoul, South KoreaNot Yet Recruiting
The Catholic University of Korea, Seoul St.MarySeoul, South KoreaRecruiting

+ 3 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT07147114