Condition: MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease · HIV (Human Immunodeficiency Virus) · Sponsor: Naga P. Chalasani
The purpose of this research study is to test the safety and effectiveness of the study drug, resmetirom, in participants with MASLD and HIV. This is a research study to test a drug that is already on the market with a population that was not included in the original clinical trials. Participants will be people over age 18 with HIV who are on antiretroviral therapy and have been diagnosed with MASLD. Researchers will compare resmetirom to placebo (a look-alike substance that contains no drug) to see if resmetirom decreases the amount of fat in the liver. Participants will: * Complete 3 screening visits to determine eligibility. * Take resmetirom or placebo every day for 24 weeks if eligible. * Have 2 MRI scans to measure the amount of fat on the liver. One will be before treatment starts and one will be at the end of 24 weeks of treatment. * Attend 3 scheduled clinic visits while on treatment for bloodwork and safety assessments. * Participate in 3 phone calls while on treatment and one phone call 4 weeks after treatment is completed to check for safety and any health changes.
This description comes directly from the study's public registry record.
Holly Crandall, BSN · 13172786200 · hrking1@iu.edu
Always discuss trial participation with your own doctor first.
| University of Alabama Birmingham | Birmingham, Alabama, United States | Not Yet Recruiting |
| UC San Diego Altman Clinical and Translational Research Institute | La Jolla, California, United States | Not Yet Recruiting |
| University of California, San Francisco | San Francisco, California, United States | Not Yet Recruiting |
| Atlantic Clinical Research Institute | West Palm Beach, Florida, United States | Not Yet Recruiting |
| Indiana University | Indianapolis, Indiana, United States | Recruiting |
| Johns Hopkins University | Baltimore, Maryland, United States | Not Yet Recruiting |
| Mt Sinai Health System | New York, New York, United States | Not Yet Recruiting |
| Duke University Medical Center | Durham, North Carolina, United States | Not Yet Recruiting |
| UT Health Houston | Houston, Texas, United States | Not Yet Recruiting |
| Virginia Commonwealth University | Richmond, Virginia, United States | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07143968