Condition: Phantom Limb Pain After Amputation · Sponsor: University of Haifa
Background: Most amputees experience phantom limb pain (PLP), for years after amputation. Virtually all PLP research to date has focused on the mechanisms of chronic PLP, ignoring the mechanisms of chronification. This research project will focus on combined neuromodulatory interventions of mirror therapy (MT) and trans direct-cranial stimulation (tDCS), applied for the first time at the acute state of PLP, with an aim to prevent its chronification and chronicity. In PLP, maladaptive plasticity associated with sensory deafferentation following an amputation is one of the contributors for excessive pain. MT is a well-accepted yet limited option, which is thought to counterbalance abnormal plasticity. tDCS is an emerging approach believed to affect the membrane potential and activity threshold of cortical neurons. tDCS analgesic effectiveness, however, is mild and short, rendering it a noneffective stand-alone treatment. The researchers' objectives are to investigate whether the combined therapy of MT and tDCS will prevent chronic PLP and improve its related clinical characteristics. In addition, the researchers will investigate the behavioral manifestations effects of the combined treatment. The investigators expect that the combined treatment applied at the acute stage of PLP will have synergistic effects on PLP intensity and thus avert its chronification. In addition, it will reduce phantom sensations, and negative affect, and will improve the sense of body ownership and ag…
This description comes directly from the study's public registry record.
Roi Treister, PhD · +972533839935 · rtreister@univ.haifa.ac.il
Shlomit Sorek, BPT MPT · +972-0507324111 · sorekshlomit@gmail.com
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| Loewenstein Hospital | Raanana, Israel, Israel | Recruiting |
| Reut Medical Center | Tel Aviv, Israel, Israel | Recruiting |
| Sheba Medical Center | Tel Aviv, Israel | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07139483