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Study identifier: NCT07138222 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

IMmune checkPoint Inhibitor Related gonAdal toxiCiTy in Premenopausal Women and Men With Melanoma

Condition: Melanoma (Skin Cancer)  ·  Sponsor: Peter MacCallum Cancer Centre, Australia

PhaseN/A
Planned participants80
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

This study aims to capture information regarding the effect of immune checkpoint inhibitor (ICI) treatment for melanoma on reproductive organ function and sex hormone levels. You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with melanoma (Stage II, III or IV) and you are planning to receive ICI treatment. Additional criteria will apply dependent upon your biological sex characteristics. All participants who choose to enroll in this study will be asked to complete a series of questionnaires and provide blood at 4 of their scheduled treatment visits. These visits are anticipated to add 30 minutes to the scheduled visit time. Male participants will also be asked to provide semen samples at 2 of their scheduled treatment visits. These visits are anticipated to add an additional 30 minutes to the scheduled visit time. No additional or novel treatments will be offered to participants who choose to enroll in this study, this is an observational study only. It is hoped this research will contribute important information regarding the potential toxic effects of ICI treatment on sexual and reproductive function in patients with melanoma who are receiving ICI treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Dr Wanda Cui, BMEDSCI, MBBS  ·  +61 3 8559 5000  ·  wanda.cui@petermac.org

Christine Dijkstra, BSC, MPH  ·  christine.dijkstra@petermac.org

Always discuss trial participation with your own doctor first.

Locations (6)

Melanoma Institute AustraliaSydney, New South Wales, AustraliaNot Yet Recruiting
Princess Alexandra HospitalBrisbane, Queensland, AustraliaNot Yet Recruiting
Cairns Base HospitalCairns, Queensland, AustraliaNot Yet Recruiting
Peter MacCallum Cancer CentreMelbourne, Victoria, AustraliaRecruiting
The Alfred HospitalMelbourne, Victoria, AustraliaNot Yet Recruiting
Austin HospitalMelbourne, Victoria, AustraliaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT07138222