Condition: Major Depressive Disorder · Sponsor: Nordsjaellands Hospital
This 26-week long, double-blinded randomized clinical trial aims to investigate the effects of semaglutide once-weekly vs. placebo on depressive symptoms in 116 patients with Major Depressive Disorder (MDD) and co-existing overweight or obesity. The treatment will be an add-on treatment to the patient's usual medication. The investigators hypothesize that adjunctive treatment with semaglutide, will lead to a significant improvement in mood compared to placebo in patients with MDD and overweight or obesity. The primary endpoint is the change in depressive symptoms measured as difference in the 12-item self-report mood questionnaire Major Depression Inventory (MDI) from start to follow-up after 26 weeks. The MDI measures the extent to which symptoms of depression have been present in the past two weeks.
This description comes directly from the study's public registry record.
Maj Vinberg, MD, DMSc · + 45 38 64 32 27 · maj.vinberg@regionh.dk
Christoffer Stanislaus, MD, ph.d.-student · Christoffer.stanislaus@regionh.dk
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| Mental Health Centre North Zealand | Hillerød, Denmark, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07136714