Condition: Alpha 1-Antitrypsin · COPD · Antibody Deficiency · Sponsor: University of Alabama at Birmingham
The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function and respiratory infections. To investigate this hypothesis, we will compare immune responses to the 20-valent pneumococcal conjugate vaccine (PCV20, Pfizer) between participants who have one abnormal copy of the SERPINA1 gene and either no COPD exacerbations, vs those with 2 or more COPD exacerbations in the past year.
This description comes directly from the study's public registry record.
David LaFon, MD · 2059343411 · dlafon@uabmc.edu
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| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07135427