Condition: Chronic Non-Specific Low Back Pain · Cognitive Decline · Longitudinal Study · Sponsor: The Hong Kong Polytechnic University
Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment. Research shows that older adults experiencing chronic pain are more likely to show worse cognitive performance compared to healthy individuals. While there is a bidirectional relationship between pain and executive functions, cognitive performance especially for some executive functions (e.g. inhibition, switching, working memory) is crucial for managing pain in older adults. Furthermore, executive dysfunctions are associated with decline in functional status among the population, particularly in performing instrumental activities in daily living. Therefore, maintaining executive function emerges as a pivotal consideration for older adults with CNSLBP. Studies provide preliminary evidence that connects brain changes with chronic pain and cognitive functions. For instance, multisite chronic pain may increase the risk of cognitive decline through structural changes like hippocampal atrophy. Besides, functional brain changes in chronic pain may reduce deactivation several key default mode network regions, predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no direct evidence supports the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. It remains unclear that whether structural changes (e.g. re…
This description comes directly from the study's public registry record.
Frank F Huang, MD · 852-5303-7752 · fan2023.huang@connect.polyu.hk
Chun Liang HSU, PhD · chun-liang.hsu@polyu.edu.hk
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| Department of Rehabilitation Sciences | Hong Kong, Hong Kong | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07134699