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Study identifier: NCT07124936 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma

Condition: Diffuse Large B Cell Lymphoma (DLBCL)  ·  Sponsor: Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

PhasePhase 1/Phase 2
Planned participants97
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The purpose of this phase 1b/2 study is to evaluate the safety, tolerability, and antitumor activity of HDM2005 in combination with standard of care in participants with diffuse large B-cell lymphoma. This study will include two arms: Cohort A (HDM2005 + R-GemOx) will enroll participants with relapsed/refractory DLBCL. Cohort B (HDM2005 + R-CHP) will enroll participants with untreated DLBCL. The study will consist of two parts: dose-escalation part and dose-expansion part.

This description comes directly from the study's public registry record.

Talk to the study team

Meiping Kong  ·  +8613735478976  ·  cxykongmeiping@eastchinapharm.com

Always discuss trial participation with your own doctor first.

Locations (21)

Peking University Cancer HospitalBeijing, Beijing Municipality, ChinaRecruiting
Fujian Cancer HospitalFuzhou, Fujian, ChinaNot Yet Recruiting
Sun Yat-sen University Cancer CenterGuangzhou, Guangdong, ChinaNot Yet Recruiting
The Affiliated Tumor Hospital of Guangxi Medical UniversityNanning, Guangxi, ChinaNot Yet Recruiting
Affiliated Tumor Hospital of Harbin Medical UniversityHarbin, Heilongjiang, ChinaNot Yet Recruiting
The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, Henan, ChinaNot Yet Recruiting
Henan Cancer HospitalZhengzhou, Henan, ChinaNot Yet Recruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hubei, ChinaNot Yet Recruiting
Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, Hubei, ChinaNot Yet Recruiting
HunanCancer HospitalChangsha, Hunan, ChinaNot Yet Recruiting
Second Affiliated Hospital of Soochow UniversitySuzhou, Jiangsu, ChinaNot Yet Recruiting
The First Affiliated Hospital Of Nanchang UniversityNanchang, Jiangxi, ChinaNot Yet Recruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07124936