Condition: Pleural Epithelioid Mesothelioma · Mesothelioma; Pleura · Neoadjuvant Chemoimmunotherapy · Sponsor: University Hospital, Antwerp
The goal of this clinical trial is to evaluate whether a combination of chemotherapy and immunotherapy can make surgery possible in adults with inoperable pleural mesothelioma (a type of cancer affecting the lung lining). The main questions it aims to answer are: Can two cycles of neoadjuvant chemotherapy and dual immunotherapy, followed by surgery, be completed safely and effectively? Does this treatment allow previously inoperable patients to become eligible for surgery and improve survival outcomes? Participants will: Receive two cycles of chemotherapy (cisplatin or carboplatin and pemetrexed) Receive dual immunotherapy (nivolumab and ipilimumab) Undergo evaluation by a multidisciplinary team to determine if surgery is possible If operable, undergo extended pleurectomy/decortication surgery Be followed for one year to assess side effects, quality of life, and survival
This description comes directly from the study's public registry record.
Prof. J. Hendriks, MD. PhD. · +3238214361 · jeroen.hendriks@uza.be
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| University Hospital Antwerp | Edegem, Antwerp, Belgium | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07121374