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Study identifier: NCT07119645 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

NT-II™ Collagen for Joint Discomfort and Function

Condition: Activity-Related Knee Discomfort · Joint Discomfort · Functional Joint Pain  ·  Sponsor: Hofseth Biocare ASA

PhaseNA
Planned participants120
Who can joinAll sexes, 20 Years to 65 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn whether a natural marine supplement called NT-II™ (Salmon Undenatured Type II Collagen) can help lower knee discomfort caused by physical activity in otherwise healthy adults. Many active people experience knee pain when performing daily movements like climbing stairs, walking long distances, or squatting, even if they do not have a medical diagnosis such as arthritis. This discomfort can limit mobility, impact exercise routines, and reduce overall quality of life. This study is being conducted to determine whether NT-II™, taken as a once-daily oral supplement, can reduce this type of activity-related knee discomfort more effectively than a commonly used joint supplement containing glucosamine and chondroitin. The main questions the study aims to answer are: Does NT-II™ reduce knee discomfort caused by repeated activity over a 12-week period? Does NT-II™ improve movement and quality of life compared to glucosamine-chondroitin? Researchers will compare two different doses of NT-II™ (240 mg and 480 mg) to glucosamine (1500 mg) plus chondroitin (1300 mg), which is used as an active comparator. All three products will be taken once daily for 12 weeks. Participants will: Take their assigned supplement daily by mouth for 12 weeks Track knee discomfort once per week using a pain rating scale called a visual analog scale (VAS) while doing an activity that usually causes discomfort, such as climbing stairs, walking, or squatting Comp…

This description comes directly from the study's public registry record.

Talk to the study team

Crawford Head of Medical R&D, MD  ·  +44 7968195497  ·  cc@hofsethbiocare.no

Christian Medical Advisor, MD  ·  +47 967 12 226  ·  chbj@hofsethbiocare.no

Always discuss trial participation with your own doctor first.

Locations (1)

Alethios Inc.San Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07119645