Condition: Pancreatic Cancer · Intraductal Papillary Mucinous Neoplasm · High-grade Pancreatic Intraepithelial Neoplasia · Sponsor: Changhai Hospital
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with early diagnosis crucial for improving survival. Due to the absence of effective screening methods, most patients are diagnosed at advanced stages. The population undergoing low-dose computed tomography (LDCT) screening significantly overlaps with those at high risk for PDAC; however, traditional imaging methods have limited sensitivity for detecting pancreatic lesions. This study utilizes the Pancreatic Cancer Detection with Artificial Intelligence (PANDA) system to enhance LDCT for pancreatic cancer screening in a prospective, multicenter, observational cohort. PANDA will analyze LDCT images, followed by a multidisciplinary team (MDT) reassessment of abnormal interpretations. Based on MDT evaluation, individuals will be recalled for further examination, placed under a personalized follow-up plan, or monitored for at least one year. The primary outcomes include pancreatic cancer detection rate, positive predictive value, consensus rate, and recall rate, while secondary outcomes focus on early-stage cancers, resectable tumors, and safety indicators such as false positive rates and unnecessary procedures. This study aims to assess the effectiveness and safety of AI-assisted LDCT for PDAC detection, providing a practical solution for improving public health and enhancing early diagnostic capabilities.
This description comes directly from the study's public registry record.
Wang Bei Lei, M.D. · 13774238083 · lilly_wang@126.com
Guo Shi Wei, M.D. · 18621500666 · gestwa@163.com
Always discuss trial participation with your own doctor first.
| Meinian Onehealth Healthcare Holdings Co., Ltd | Shanghai, Shanghai Municipality, China | Recruiting |
| Ruici Medical Examination Institution | Shanghai, Shanghai Municipality, China | Recruiting |
| Changhai Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Jiaxing University Affiliated Second Hospital | Jiaxing, Zhejiang, China | Recruiting |
| Ningbo University Affiliated People's Hospital | Ningbo, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07117045