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Study identifier: NCT07111559 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Lacunar Stroke hyperAcute Clinical Utilization of Novel Approach Regimens: Rt-PA vs. DAPT Randomised Clinical Trial

Condition: Lacunar Stroke · Stroke · Ischemic Stroke  ·  Sponsor: Nippon Medical School

PhasePhase 4
Planned participants500
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if a combination of antiplatelet drugs works better than intravenous tissue plasminogen activator to treat small ischemic stroke (lacunar stroke). The main questions it aims to answer are: Is a combination of antiplatelet drugs non-inferior to the current standard tissue plasminogen activator treatment? Does a combination of antiplatelet drugs reduce the bleeding complications than tissue plasminogen activator? Researchers will compare a combination of antiplatelet drugs to tissue plasminogen activator to see if a combination of antiplatelet drugs works to treat small ischemic stroke (lacunar stroke). Participants will: Take a combination of antiplatelet drugs or be given intravenous tissue plasminogen activator Check the neurological status 3 months after stroke, in-person, by phone, or by mail.

This description comes directly from the study's public registry record.

Talk to the study team

Yuki Sakamoto  ·  +81-3-3822-2131  ·  yuki-sakamoto@nms.ac.jp

Always discuss trial participation with your own doctor first.

Locations (28)

University of Yamanashi HospitalChūō, JapanRecruiting
University of Fukui HospitalFukui, JapanRecruiting
Fukuoka Red Cross HospitalFukuoka, JapanRecruiting
Ota Memorial HospitalFukuyama, JapanRecruiting
Kansai Medical University HospitalHirakata, JapanRecruiting
Kagoshima City HospitalKagoshima, JapanRecruiting
Kagoshima Medical CenterKagoshima, JapanRecruiting
Shioda HospitalKatsuura, JapanRecruiting
St. Marianna University School of Medicine HospitalKawasaki, JapanRecruiting
The Jikei University West Medical CenterKomae, JapanRecruiting
Kawasaki Medical School HospitalKurashiki, JapanRecruiting
Japanese Red Cross Kyoto Daini HospitalKyoto, JapanRecruiting

+ 16 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07111559