● Recruiting

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

Condition: Non-small Cell Lung Cancer · Sponsor: BioNTech SE

PhasePhase 1/Phase 2

Planned participants420

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

This is a multi-site, open-label, dose-finding study, consisting of Parts 1, 2a, and 2b to investigate the combination of BNT326 with BNT327 in participants with relapsed, progressive as well as treatment-naïve, advanced/metastatic non-small cell lung cancer (NSCLC). This study will enroll adult participants with histologically or cytologically confirmed NSCLC that is advanced (i.e., either metastatic or recurrent tumors with no known curative treatment available).

This description comes directly from the study's public registry record.

Talk to the study team

BioNTech clinical trials patient information · +49 6131 9084 · patients@biontech.de

Always discuss trial participation with your own doctor first.

Locations (68)

Stanford Cancer Institute	Stanford, California, United States	Recruiting
Yale University	New Haven, Connecticut, United States	Recruiting
Moffit Cancer Center	Tampa, Florida, United States	Recruiting
Dana-Farber Cancer Institute	Boston, Massachusetts, United States	Recruiting
Henry Ford Health System	Detroit, Michigan, United States	Recruiting
Memorial Sloan Kettering Cancer Center	New York, New York, United States	Recruiting
Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center	Cleveland, Ohio, United States	Recruiting
University of Texas M. D. Anderson Cancer Center	Houston, Texas, United States	Recruiting
NEXT Virginia	Fairfax, Virginia, United States	Recruiting
Cancer Research SA	Adelaide, Australia	Recruiting
St George Private Hospital	Kogarah, Australia	Recruiting
John Flynn Private Hospital	Tugun, Australia	Recruiting

+ 56 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07111520