Condition: Mechanical Ventilation · Weaning Failure · Sponsor: Radboud University Medical Center
Prolonged weaning from mechanical ventilation is a common and serious challenge in the ICU, associated with increased morbidity, mortality, and length of stay. Diaphragm dysfunction plays a key role in weaning failure, and current strategies to support respiratory muscle function are limited. Levosimendan is a calcium sensitizer that enhances cardiac and skeletal muscle contractility, including the diaphragm, without increasing oxygen demand. The investigators hypothesize that treatment with Levosimendan in difficult-to-wean ICU patients will improve diaphragm function and thereby shorten the duration of mechanical ventilation compared to placebo.
This description comes directly from the study's public registry record.
Esther de Leijer, MD · +31243668420 · esther.deleijer@radboudumc.nl
Leo Heunks, MD, PhD · leo.heunks@radboudumc.nl
Always discuss trial participation with your own doctor first.
| Rijnstate Ziekenhuis Stichting | Arnhem, Gelderland, Netherlands | Recruiting |
| Intensive Care Medicine, Radboud University | Nijmegen, Gelderland, Netherlands | Recruiting |
| Canisius Wilhelmina Ziekenhuis | Nijmegen, Gelderland, Netherlands | Recruiting |
| Jeroen Bosch Ziekenhuis Stichting | 's-Hertogenbosch, North Brabant, Netherlands | Recruiting |
| Catharina Ziekenhuis Stichting | Eindhoven, North Brabant, Netherlands | Not Yet Recruiting |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) | Rotterdam, South Holland, Netherlands | Not Yet Recruiting |
| Sint Franciscus Vlietland Groep Stichting | Rotterdam, South Holland, Netherlands | Recruiting |
| Maasstad Ziekenhuis Stichting | Rotterdam, South Holland, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07105202