Condition: Episodic Migraine · Chronic Migraine · Medication Overuse Headache · Sponsor: IRCCS San Raffaele Roma
Approved by the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) starting in 2018, anti-CGRP monoclonal antibodies (anti-CGRP mAbs) represent the first true revolution in the preventive treatment of migraine due to their selectivity and specificity. To date, four anti-CGRP mAbs have been developed for the preventive treatment of migraine: eptinezumab, erenumab, fremanezumab, and galcanezumab.Anti-CGRP mAbs constitute not only the first specific and selective treatment for the prevention of migraine but also the most extensively studied pharmacological category in this field, considering the vast and complex populations examined. The clinical effects of the various mAbs are substantially comparable and are characterized by several fundamental aspects: * High efficacy in both episodic and chronic migraine, with the presence of super-responders who experience a reduction in the average monthly number of migraine days of \>75% (or even 100%) compared to before treatment. * Efficacy that is independent of the clinical form of migraine - with or without aura - and regardless of whether there is analgesic overuse. * Efficacy maintained even in the presence of depressive or anxious comorbidities. * Rapid onset of action (even more pronounced with eptinezumab), with the therapeutic effect appearing within the first week in most cases. * Excellent tolerability with an absence of class-specific adverse events. * Outstanding treatment adherence and a very low ra…
This description comes directly from the study's public registry record.
Piero Barbanti, MD, PhD · +390652254318 · piero.barbanti@sanraffaele.it
Cinzia Aurilia · +390652254318 · cinzia.aurilia@sanraffaele.it
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| Istituto Auxologico Italiano IRCCS | Milan, Italy, Italy | Recruiting |
| IRCCS San Raffaele | Rome, Italy, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07103694