Condition: Normal Pressure Hydrocephalus · Sponsor: Imperial College London
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is diverted from the brain. Not all patients with iNPH respond to CSF-shunting however. The reasons for this are uncertain. Aim 1: To understand if specific nerve pathways (white matter tracts) that are near ventricles are damaged in patients that respond to shunting as opposed to those that do not. Aim 2: Can we explain shunt non-responsiveness by screening for dementia like illnesses (neurodegeneration) using a large array of methods. Aim 3: To understand whether wearable activity and bed sleep monitors are palatable in a NPH population and to understand if these metrics relate to quality of life. Aim 4: To see whether self-administered digital cognitive assessments can measure improvements pre and post surgery.
This description comes directly from the study's public registry record.
Chris Carswell · +44 20311 1234 · NPH@imperial.ac.uk
Harvey G Burns · +44 20311 1234 · NPH@imperial.ac.uk
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| Imperial College Healthcare NHS Trust | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07103681