Condition: Locally Advanced Pancreatic Ductal Adenocarcinoma · Sponsor: West China Hospital
This study is a single-arm phase II clinical trial. The study targets patients aged 18-75 years with ECOG performance status 0-2, diagnosed with locally advanced pancreatic ductal adenocarcinoma based on comprehensive assessment of pathology and imaging studies (CT or MRI). Participating patients will receive the GnP regimen every 21 days (nab-paclitaxel 125mg/m² ivgtt on days 1 and 8 + gemcitabine 1000mg/m² ivgtt on days 1 and 8, repeated every 21 days) combined with serplulimab (200mg ivgtt Q3W). In the second cycle, patients will receive SBRT targeting the primary tumor and/or retroperitoneal lymph nodes: 6.6Gy×5 fractions, 7Gy×5 fractions, or 8Gy×5 fractions, administered every other day with radiotherapy completed in 5 sessions (specific selection determined by investigators based on lesion size and organs at risk \[OAR\] assessment). Comprehensive evaluation including tumor markers and CT scans will be performed every 2 cycles with multidisciplinary team (MDT) review, and patients who meet surgical criteria will undergo radical resection surgery.
This description comes directly from the study's public registry record.
Dan Cao, MD · +8618980605963 · caodan@scu.edu.cn
Ke Cheng, MD · +8618980607330 · 183818128@qq.com
Always discuss trial participation with your own doctor first.
| West China Hospital, Sichuan University | Chengdu, Sichuan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07101679