Condition: Breast Cancer · Sponsor: Genentech, Inc.
The purpose of this study is to assess the safety of GDC-4198 alone and in combination with giredestrant and also the efficacy of GDC-4198 + giredestrant versus abemaciclib + giredestrant in participants with locally advanced or metastatic ER+, HER2- breast cancer. The study consists of 2 phases: Phase Ib and Phase II. Phase Ib will evaluate the safety and pharmacokinetics (PK) of GDC-4198 alone and in combination with giredestrant. Phase II stage will compare the activity and safety of GDC-4198 and giredestrant with abemaciclib and giredestrant.
This description comes directly from the study's public registry record.
Reference Study ID Number: GO46021 https://forpatients.roche.com/ No attachments to email below. · 888-662-6728 (U.S. Only) · global-roche-genentech-trials@gene.com
Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
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| City of Hope | Duarte, California, United States | Recruiting |
| City of Hope - Orange County Lennar Foundation Cancer Center | Irvine, California, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| UCSF Helen Diller Family CCC | San Francisco, California, United States | Recruiting |
| Sylvester Comprehensive Cancer Center | Miami, Florida, United States | Recruiting |
| Moffitt Cancer Center | Tampa, Florida, United States | Recruiting |
| Winship Cancer Institute of Emory University | Atlanta, Georgia, United States | Recruiting |
| City of Hope® Cancer Center Chicago | Zion, Illinois, United States | Recruiting |
| Barbara Ann Karmanos Cancer Institute | Detroit, Maine, United States | Recruiting |
| Washington University Siteman Cancer Center | St Louis, Missouri, United States | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick, New Jersey, United States | Recruiting |
| New York Cancer & Blood Specialists | East Patchogue, New York, United States | Recruiting |
+ 40 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07100106