Condition: Recurrent Diffuse Large B-Cell Lymphoma · Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified · Recurrent Grade 3b Follicular Lymphoma · Sponsor: Fred Hutchinson Cancer Center
This phase I/II trial tests the safety, side effects, and best dose/regimen of ST-067 in combination with CD19-directed chimeric antigen receptor (CAR) T-cell therapy (liso-cel) and how well it works in treating patients with large B-cell lymphoma (LBCL) that has come back after a period of improvement (recurrent) or LBCL that has not responded to previous treatment (refractory). ST-067 is an engineered variant of the human cytokine interleukin-18 that may help the immune system kill cancer cells. Lisocabtagene maraleucel (liso-cel) is an autologous CAR T-cell therapy prepared using the person's own immune system (a group of cells, tissues, and organs that protect the body from attack by bacteria, viruses, and cancer cells) to fight the cancer. Giving ST-067 in combination with liso-cel may better treat patients with relapsed/refractory LBCL.
This description comes directly from the study's public registry record.
Immunotherapy Intake Coordinator · 206-606-4668 · immunotherapy@fredhutch.org
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| Fred Hutch/University of Washington Cancer Consortium | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07098364