Condition: Muscle Invasive Bladder Urothelial Carcinoma · Stage II Bladder Cancer AJCC v8 · Stage IIIA Bladder Cancer AJCC v8 · Sponsor: NRG Oncology
This phase III trial compares the effect of decreased number of radiation (ultra-hypofractionated) treatments to the usual radiation number of treatments (hypofractionation) with standard of care chemotherapy, with cisplatin, gemcitabine or mitomycin and 5-fluorouracil for the treatment of patients with muscle invasive bladder cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a short period of time. Ultra-hypofractionated radiation therapy delivers radiation over an even shorter period of time than hypofractionated radiation therapy. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill tumor cells. Chemotherapy drugs, such as mitomycin-C and 5-fluorouracil (5-FU), work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ultra-hypofractionated radiation may be equally effective as hypofractionated therapy for patients with muscle invasive bladder cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | Recruiting |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| UCHealth - Cherry Creek | Denver, Colorado, United States | Recruiting |
| UCHealth Highlands Ranch Hospital | Highlands Ranch, Colorado, United States | Recruiting |
| UCHealth Lone Tree Health Center | Lone Tree, Colorado, United States | Recruiting |
| Beebe Medical Center | Lewes, Delaware, United States | Recruiting |
| Beebe South Coastal Health Campus | Millville, Delaware, United States | Recruiting |
| Helen F Graham Cancer Center | Newark, Delaware, United States | Recruiting |
+ 199 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07097142