Condition: Rectal Cancer · Sponsor: Ain Shams University
Several trials showed that total neoadjuvant treatment (TNT) in stage II/III rectal cancer patients had better outcomes when compared with standard neoadjuvant long-course radiotherapy (CRT). Recently, based on the RAPIDO and POLISH II trials a short course radiotherapy (SCRT)-including TNT strategy had better oncologic outcomes and comparable toxicities. Moreover, cost-effectively, an SCRT-including TNT strategy is more convenient than a CRT-based TNT approach. In addition, systemic chemotherapy is often used to treat occult or micrometastatic disease in intermediate and locally advanced rectal cancer. However, the timing of chemotherapy delivery remains a topic of debate. In this context, and since rapid access to radiotherapy treatment is limited, especially in developing countries, a TNT strategy whereby adjuvant chemotherapy is replaced by systemic chemotherapy delivered before and after SCRT according to a "sandwich" treatment can avoid delays in treatment start with equivalent outcomes.
This description comes directly from the study's public registry record.
Hadeer H Mohamed, MSc · +201061214926 · hadeer.h.mohamed20@gmail.com
Sara E Zaki, MD · sara.zaki@med.asu.edu.eg
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| Clinical oncology and nuclear medicine Department, Faculty of medicine, Ain Shams University | Cairo, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07095439