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Study identifier: NCT07094711 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Safety, Immunogenicity, and Efficacy of Therapeutic Mycobacterium Bovis BCG (BOOST)

Condition: Mycobacterium Avium-intracellulare Infection · Mycobacterium Infections, Nontuberculous  ·  Sponsor: University of Virginia

PhasePhase 2
Planned participants48
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out if the Mycobacterium bovis Bacillus Calmette Guerin (BCG) vaccine can be used safely to treat Mycobacterium avium complex (MAC) lung disease. Researchers will compare responses from patients with MAC lung disease after receiving an injection of BCG or placebo (a look-alike substance that contains no drug) Participants in the study: * Receive a BCG or placebo injection at UVA study center on Day 0 * Come to UVA study center on Day 60 * Come to UVA study center at the end of the study * Answer surveys and questionnaires about how you are doing * Have blood drawn 3 times, on injection day, day 60, and at end of study * Give the study team personal and demographic information * Discuss any new symptoms with the study team * Provide monthly sputum samples per usual care

This description comes directly from the study's public registry record.

Talk to the study team

Eric R Houpt, M.D.  ·  +1 434 243 9326  ·  erh6k@virginia.edu

Tania A Thomas, MD  ·  434-243-9592  ·  tat3x@virginia.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Virginia HealthCharlottesville, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07094711