Condition: Melanoma · Fertility · Sponsor: Intergruppo Melanoma Italiano
Melanoma survivorship in reproductive-age women is increasing due to the advent of effective therapies in the curative setting. However, while the impact on fertility and ovarian function of chemotherapy agents is well known, there is still a lack of consistent data regarding novel the Mitogen-activated protein kinase (MAP) kinase pathway inhibitors and immune-checkpoint inhibitors (ICIs) used in melanoma. A recent study showed that a single course of anti-PD-1 (PD, Programmed cell death protein 1) or anti-CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) reduced both the number and quality of oocytes in mice through an immune-mediated mechanism. In particular, primordial follicle damage cannot be restored, leading to relevant clinical implications. The study aims to help to determine the impact of MAP kinase pathway inhibitors and ICIs on reproductive outcomes, and whether clinicians should discuss (and in what terms) fertility preservation techniques in reproductive-age women receiving ICIs and MAP kinase pathway inhibitors in the adjuvant setting.
This description comes directly from the study's public registry record.
Mario Mandalà · 0039 0755784211 · mario.mandala@unipg.it
Always discuss trial participation with your own doctor first.
| Ospedale Oncologico "Giovanni Paolo II" | Bari, Italy | Not Yet Recruiting |
| IRCCS Ospedale Policlinico San Martino, Oncologia Medica 2 | Genova, Italy | Not Yet Recruiting |
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milan, Italy | Not Yet Recruiting |
| Azienda Ospedaliero-Universitaria, Modena | Modena, Italy | Not Yet Recruiting |
| Istituto Nazionale Tumori "Fondazione Pascale" | Naples, Italy | Not Yet Recruiting |
| IOV Istituto Oncologico Veneto | Padova, Italy | Not Yet Recruiting |
| Azienda Ospedaliera Santa Maria della Misericordia - Unità di Oncologia Medica. | Perugia, Italy | Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma, Italy | Not Yet Recruiting |
| Università degli Studi di Siena - U.O.C. Immunoterapia Oncologica Azienda Ospedaliera Universitaria Senese | Siena, Italy | Not Yet Recruiting |
| Università di Torino - Clinica Dermatologica | Torino, Italy | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07092670